It is related to your sample concentration. For high solids , I would suggest TA DSC. For low solid concentration (less than 20%), you should have bigger size of protein in pan. It is also related to your protein type. For example, for soy proteins, you need high temp sometimes more than 100 deg.
Also, you can see some of my publication in this respect.
Any DSC can trace protein denaturation. We have done numerous works on the issue and if you have any problem consult my publication or e-mail me at [email protected].