I had problems during preparation of lipophilic statin loading chitosan nanoparticles.
Did you try to use a surfactant such as Tween 20?
Thanks for your comment. Could you please tell me the concentration of TW20?
It depends on your molecule or active agent. You can find some examples in the literature.
Its better that you check HLB system. when you used some materials for preparing nanoparticles, HLB is so important. one of best surfactant for you is tween group and I suggest you tween 80 . you can find so many paper about Chitosan and tween 80
Thank you for the answer, I will try.
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