Do you think that in the papers, which indicate an increase of dementia and use of PPI, HP infection has been properly evaluated?

Recently there are many reports that indicate the association between use of Proton Pump Inhibitors (PPI) and increased risk of dementia. On the other hand are well-known correlations between...

06 July 2016 5,315 28 View

Does anyone know if it was shown that when AhR is hyperactivated (by dioxin or other exogenous drugs) there is reduced activity of HIF1-alpha?

Both AhR and HIF1-alpha form heterodimers with ARNT (HIF1-beta). There are many papers that indicate a possible use of drugs that determine an hyperactivity of AhR in the treatment of various...

10 November 2015 6,613 3 View

What do you think about circulating nucleic acids damage DNA of healthy cells by integrating into their genomes.?

Although I am not able to evaluate the methods I believe that this work just published (attached) offers the expected results, for new ways to look at the pathophysiology. If the results can be...

02 March 2015 5,527 10 View

What evidence is there that these is no enzyme Ornithine cyclodeaminase-like activity in mammals?

02 March 2015 3,698 4 View

What is the weight of the pharmaceutical companies in addressing clinical pathways for diagnosis and treatment?

I begin with this interview with Dr. Ablin PSA antigen's discoverer which was published a few months ago (attached). But this is a well known case. What impact has the introduction of new genetic...

11 December 2014 7,139 5 View

Does anyone know anything about the metabolism of proline in Tuberous Sclerosis?

09 October 2014 197 19 View

Immunophenotypic characterization of cell lines (Tuberous Sclerosis/Lymphangioleiomyomatosis) before and after addition of rapamycin or analogues.

I had already asked a question about the phenotype of residual disease (visceral lesions of the "tuberous sclerosis" or lymphangioleiomyomatosis) after treatment with rapamycin or analogues. There...

06 July 2014 9,192 3 View

Can music help with the rehabilitation of aphasic patients?

I believe the approach of Miranda Yeoh is very important. Many years ago, during medical school, I studied for two years (before turning to surgical pathology) the rehabilitation of aphasic...

03 April 2014 6,297 22 View

What do you think of the criteria for determining the malignancy of "Oncocytic adrenocortical neoplasm"?

What do you think of the criteria for determining the malignancy of "Oncocytic adrenocortical neoplasm" (Lin-Weiss-Bisceglia (LWB) system)? I refer in particular to venous invasion if this is the...

02 March 2014 7,171 0 View

Does anyone know if in breast cancer there is some ralation between positivity for HER2/neu and negativity for progesterone receptors?

The rationale may be non-genomic inhibition of progesterone receptors via mTOR pathway that suggests an activation of the growth factors. In other words, a therapy with trastuzumab etc. might be...

09 October 2013 1,379 17 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

No title

02 March 2021 3,060 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View