I could not find any specific work on PP242 and Tuberous Sclerosis and / or lymphangioleiomyomatosis. Can someone tell me something about ?

PP242 Counteracts Glioblastoma Cell Proliferation, Migration... mTORC1 and mTORC2 in cancer and the tumor microenvironment...

05 June 2018 7,254 3 View

Do you think that in the papers, which indicate an increase of dementia and use of PPI, HP infection has been properly evaluated?

Recently there are many reports that indicate the association between use of Proton Pump Inhibitors (PPI) and increased risk of dementia. On the other hand are well-known correlations between...

06 July 2016 5,315 28 View

Does anyone know if it was shown that when AhR is hyperactivated (by dioxin or other exogenous drugs) there is reduced activity of HIF1-alpha?

Both AhR and HIF1-alpha form heterodimers with ARNT (HIF1-beta). There are many papers that indicate a possible use of drugs that determine an hyperactivity of AhR in the treatment of various...

10 November 2015 6,613 3 View

What do you think about circulating nucleic acids damage DNA of healthy cells by integrating into their genomes.?

Although I am not able to evaluate the methods I believe that this work just published (attached) offers the expected results, for new ways to look at the pathophysiology. If the results can be...

02 March 2015 5,527 10 View

What evidence is there that these is no enzyme Ornithine cyclodeaminase-like activity in mammals?

02 March 2015 3,698 4 View

What is the weight of the pharmaceutical companies in addressing clinical pathways for diagnosis and treatment?

I begin with this interview with Dr. Ablin PSA antigen's discoverer which was published a few months ago (attached). But this is a well known case. What impact has the introduction of new genetic...

11 December 2014 7,139 5 View

Does anyone know anything about the metabolism of proline in Tuberous Sclerosis?

09 October 2014 197 19 View

Immunophenotypic characterization of cell lines (Tuberous Sclerosis/Lymphangioleiomyomatosis) before and after addition of rapamycin or analogues.

I had already asked a question about the phenotype of residual disease (visceral lesions of the "tuberous sclerosis" or lymphangioleiomyomatosis) after treatment with rapamycin or analogues. There...

06 July 2014 9,192 3 View

Can music help with the rehabilitation of aphasic patients?

I believe the approach of Miranda Yeoh is very important. Many years ago, during medical school, I studied for two years (before turning to surgical pathology) the rehabilitation of aphasic...

03 April 2014 6,297 22 View

Does anyone know if in breast cancer there is some ralation between positivity for HER2/neu and negativity for progesterone receptors?

The rationale may be non-genomic inhibition of progesterone receptors via mTOR pathway that suggests an activation of the growth factors. In other words, a therapy with trastuzumab etc. might be...

09 October 2013 1,379 17 View

IHC on mouse liver hepatocytes?

Can anyone help me choose primary antibodies for mouse liver hepatocytes and also in conjunction Cd8 cells. Also Cd3 cells. I want to look at hepatocytes and adjacent immune cells in mice with...

01 March 2021 6,953 1 View

Isolates of Hymenoscyphus fraxineus?

Dear Dr. Cai, my name is Simone Prospero and I work in the team of Phytopathology at the Swiss Federal Institute for Forest Snow and Landscape Research (WSL;...

01 March 2021 1,133 1 View

Reagents for histology slides?

Dear all, I am planning to study histology and want to do that at home. I have only stained a blood smear with Giemsa but now want to try a wider range of animal tissues. What reagents will I...

24 February 2021 5,430 3 View

Does anyone have any experience with the Motic EasyScan Pro Slide Scanner?

I am interested in purchasing a slide scanner for histology and was presented with the Motic EasyScan Pro but I have never heard of the company, nor know of anyone who has used the system. Can...

11 February 2021 2,416 2 View

Should the AUC in a concentration-time graph of a subcutaneous implant be roughly the same for poeple?

I have 2 concentration time curves of a subcut drug implant. the first group has a peak around the 50 day mark where as the second group does not. Both groups received the same implant by the same...

10 February 2021 2,305 3 View

Which Journals would you advise to submit a Letter which briefly talks about neurosurgical treatment of neuro-oncological patient during Sars-COV-2?

Possibily not an open access journal which does not add any publishing costs once being accepted. Thank you in advance

09 February 2021 717 6 View

Having trouble mounting the sections on the slides for IHC staining, what solution should I use?

Hello everyone, I just started learning IHC staining and I have some frozen sections to practice with in a 96-well plate. I'm having trouble mounting the sections on the slide, a colleague told me...

08 February 2021 6,880 3 View

How to fix and protect blood clots for histology ?

Hi, I encounter some problems, I need to my research to fix and cryoprotec some blood clot for histology analyses. Mys current protocol is the following : 48h of para formaldehyde 4% and 7 days of...

07 February 2021 3,756 3 View

Which isomer of xylene do you use in hystology ?

Which isomer of xylene do you use for the preparation of histological tissue sections - meta para or ortho?

02 February 2021 833 4 View

How to perform CV by using potentiostat?

I have deposited a metal oxide thin film of glass plate, A conductive thin film was also deposited on the glass substrate before the deposition of metal oxide film. How can I perform its CV from a...

01 February 2021 7,710 3 View