Maurizio Pea

14 Questions 118 Answers 0 Followers

Questions related from Maurizio Pea

I could not find any specific work on PP242 and Tuberous Sclerosis and / or lymphangioleiomyomatosis. Can someone tell me something about ?

PP242 Counteracts Glioblastoma Cell Proliferation, Migration... mTORC1 and mTORC2 in cancer and the tumor microenvironment...

06 June 2018 7,367 3 View

Do you think that in the papers, which indicate an increase of dementia and use of PPI, HP infection has been properly evaluated?

Recently there are many reports that indicate the association between use of Proton Pump Inhibitors (PPI) and increased risk of dementia. On the other hand are well-known correlations between...

07 July 2016 5,398 28 View

Does anyone know if it was shown that when AhR is hyperactivated (by dioxin or other exogenous drugs) there is reduced activity of HIF1-alpha?

Both AhR and HIF1-alpha form heterodimers with ARNT (HIF1-beta). There are many papers that indicate a possible use of drugs that determine an hyperactivity of AhR in the treatment of various...

11 November 2015 6,699 3 View

What do you think about circulating nucleic acids damage DNA of healthy cells by integrating into their genomes.?

Although I am not able to evaluate the methods I believe that this work just published (attached) offers the expected results, for new ways to look at the pathophysiology. If the results can be...

03 March 2015 5,623 10 View

What evidence is there that these is no enzyme Ornithine cyclodeaminase-like activity in mammals?

Mu-crystallin (CRYM 16p13.11-p12.3. in human) is a lens structural protein in diurnal marsupials and an enzyme in mammalian possible involved in the potassium-ion recycling system; in addition...

03 March 2015 3,772 4 View

What is the weight of the pharmaceutical companies in addressing clinical pathways for diagnosis and treatment?

I begin with this interview with Dr. Ablin PSA antigen's discoverer which was published a few months ago (attached). But this is a well known case. What impact has the introduction of new genetic...

12 December 2014 7,233 5 View

Does anyone know anything about the metabolism of proline in Tuberous Sclerosis?

In the 1980s Tanaka pointed out, in some publications, an abnormal metabolism of proline in patients with tuberous sclerosis (a prototype syndrome of hyperfunction of mTOR pathway), probably...

10 October 2014 284 19 View

Immunophenotypic characterization of cell lines (Tuberous Sclerosis/Lymphangioleiomyomatosis) before and after addition of rapamycin or analogues.

I had already asked a question about the phenotype of residual disease (visceral lesions of the "tuberous sclerosis" or lymphangioleiomyomatosis) after treatment with rapamycin or analogues. There...

07 July 2014 9,284 3 View

Can music help with the rehabilitation of aphasic patients?

I believe the approach of Miranda Yeoh is very important. Many years ago, during medical school, I studied for two years (before turning to surgical pathology) the rehabilitation of aphasic...

04 April 2014 6,393 22 View

What do you think of the criteria for determining the malignancy of "Oncocytic adrenocortical neoplasm"?

What do you think of the criteria for determining the malignancy of "Oncocytic adrenocortical neoplasm" (Lin-Weiss-Bisceglia (LWB) system)? I refer in particular to venous invasion if this is the...

03 March 2014 7,266 0 View

Does anyone know if in breast cancer there is some ralation between positivity for HER2/neu and negativity for progesterone receptors?

The rationale may be non-genomic inhibition of progesterone receptors via mTOR pathway that suggests an activation of the growth factors. In other words, a therapy with trastuzumab etc. might be...

10 October 2013 1,474 17 View

Could HIF1B, which constitutes together with HIF1-alpha, the "HIF1 heterodimer", be one of the links between mTOR and the estrogen receptor?

Could HIF1B (DIOXIN RECEPTOR, ARYL HYDROCARBON RECEPTOR NUCLEAR translocator, ARNT, hypoxia-inducible factor 1 subunit BETA, BETA-HIF1), which constitutes together with HIF1-alpha, the "HIF1...

08 August 2013 4,161 3 View

What is the immunophenotype of angiomyolipomas residual disease after treatment with mTOR inhibitors?

After rapamycin, TORC1 and TORC2 specific inhibitors were introduced in the phase of clinical trial for the treatment of angiomyolipomas (TSC / no-TSC). I was expecting some better results from...

08 August 2013 3,230 3 View

Is TOR (Target Of Rapamycin) overactive in plants’ galls?

Does anyone know if it has been proven if there is hyperactivation of TOR (target of rapamycin) in the galls of plants? I searched but could not find anything specific. I ask this question because...

08 August 2013 6,602 12 View