Teach the immuno system of the patients to combat the cancer. I mean there are some strategies in this field that has got some success. It's a novel but powerful area. However, there is still a long way to go.

Thanks for the response Aiken, we are currently have a tumour immunology poster being done by Jacintha O'Sullivan, it should be out in the next few months!

How about the Menin/MLL pathway in leukemia? It's a hot topic recently. Have you ever tried it?

how about HIF and hypoxia in cancer?

Hi Lara, thanks for the input, good idea, we currently have an card on hypoxia; http://docs.abcam.com/pdf/metabolism/AKR-Hypoxia-Card.pdf

We are currently preparing some work on ROS also to tie in with our hypoxia work and hopefully this will be released soon!

Whatever about hippo pathway ,stem celles ADN cancer. Lots of rev articles thaïs year

It's all about the stroma! :)

Seriously though, the stromal component of tumours is still hugely overlooked by many researchers. It is fast becoming the topic to work on..

Thanks guys, we are currently designing a hippo pathway poster which should have a stem cell focus and be out soon enough!

@Matthew, what would you have in mind exactly for a stroma poster? We shortly will have one on Tumour immmunology, I don't have the exact content for this yet.

I agree with Matthew and Constantinos! PI3K delta inhibition for the treatment of B cell malignancies has reitterated hugely important stromal interactions.

Sorry Sean, I completely neglected your question..

The paper above, that Constantinos suggests (particularly figure 1) is exactly the kind of thing I was thinking of. First of all, showing what makes up tumour stroma in the tumour microenvironment and secondly what roles each of those cells types has/potentially has in regard to cancer progress. For example, how cancer associated fibroblasts can over express growth factors, remodel the ECM, things like..

Happy to make more suggestions if a tumour stroma poster is a real possibility!

How about ubiquitylation or sumoylation pathways in cancer?

yes you can only look for one such PTM or a whole lot of them in cancer and its biology.

Just back from the Cell symposia, Hallmarks of Cancer, and like everyone seems to mentioning it is all about the stroma, CAFs, MAFs, Cancer Stem Cells. Exactly like the article you mention Constantinos and what Lisa Coussens discussed identifying regulatory cells involved in the microenvironment will hopefully circumvent resistance.

I will be attending the NCRI next week in Liverpool if anyone would like to discuss this in person?