Drug molecules can interact with each other intermolecularly without changing the structure and chemically with a change in structure. they undergo changes in structure in the stomach under the action of cell enzymes. Drug molecules can react with each other. This is usually written about their incompatibility. Their removal from the body in the form of metabolites is being studied.
As you know, nanoparticles are obtained by dispersing large particles or condensation, that is, combining molecules into nanoparticles. Nanoparticles cannot be obtained in the body through the process of nucleation. But combining drug molecules through ionic bonding or hydrophobic interaction is possible. This is not yet done due to the difficulty of controlling the interaction in the body.
They do it differently, outside the body they place the medicine in a micelle, liposome, and then send it into the body.