bodipy moiety are high polar nature .so its are bottom of TLC PALTE up to 20;80(ethyl acetate;hexane) mixture so its binding in SiO2 SO YIELD is so decreased. how to remove DDQ from reaction mixture?
Muhammad Ilyas
When working with BODIPY compounds and attempting to remove DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) from a reaction mixture, it is essential to consider both the polarity and the affinity of the compounds involved. Here are some strategies to help remove DDQ effectively:
Column Chromatography:
- Use a column with a less polar stationary phase, such as alumina, if silica is causing binding issues.
- Adjust the polarity of the mobile phase to enhance the separation. For example, try a gradient starting from a less polar solvent mixture (e.g., hexane) and gradually increasing the polarity (e.g., adding ethyl acetate).
- Precipitation: If your BODIPY compound is less soluble in certain solvents, try to precipitate it out by adding a non-solvent (e.g., methanol or diethyl ether) to the reaction mixture, then filter to remove the solid. Liquid-Liquid Extraction: Perform an extraction using a biphasic solvent system. DDQ is more soluble in organic solvents like dichloromethane (DCM) or chloroform. Washing the reaction mixture with these solvents can help separate DDQ from your BODIPY compound. Use water or an aqueous solution to remove any water-soluble impurities.
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Bintu Kumar
You can use DCM and hexane mixture of that solvent replace of EtOAc: hexane, for the purification of BODIPY anx porphyin derivatives
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