Could someone explain to me how I can make a eugenol nanoemulsion that appears translucent? I've been working on it, but it always results in a cloudy, white macroemulsion.
Read about examples of nanoemulsion preparation and try to adopt to your system. You might learn much more that receiving a recipe.
Hi !
You can prepare a translucent eugenol nanoemulsion by using a high-energy emulsification method involving high-pressure homogenization or ultrasonication as to achieve droplet sizes below 100 nm, which ensures translucency due to minimal light scattering. Formulation starts by preparing the oil phase with eugenol (typically 1–5% w/v) and mix with surfactants like Tween 80 (Polysorbate 80) and co-surfactants such as PEG 400 or ethanol in a 2:1 or 3:1 surfactant-to-oil ratio (Smix). The aqueous phase is usually distilled water or phosphate-buffered saline. This mixture is pre-emulsified using a magnetic stirrer or rotor-stator homogenizer at 10,000–15,000 RPM for 5–10 minutes. The coarse emulsion will be formed which you have to subject for high-pressure homogenization at 15,000–20,000 psi for 3–5 cycles or probe ultrasonication at 20 kHz for 5–10 minutes in pulse mode with cooling. The resulting nanoemulsion which will be formed is expected to exhibit droplet sizes below 100 nm and a polydispersity index (PDI) < 0.3, which you can confirm by DLS (Dynamic Light Scattering) analysis.
This formulation approach ensures that the eugenol nanoemulsion which you have formulated is physically stable, pharmaceutically acceptable, and visually translucent, suitable for topical, oral, or parenteral applications depending on the excipient compatibility.
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