How to maximize encapsulation efficiency of a drug in micelles?
There are various approaches to maximize encapsulation efficacy of drug in micelle. Among them, one is increasing polymer volume fraction and packing fraction but decreases with increasing head-head interaction strength. (refrence paper: Article Encapsulation Efficiency and Micellar Structure of Solute-Ca...
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Next is the nature of the drug also play a vital role during selection of the specific polymers to promote the encapsulation. eg. the effect of hydrophobic solute particles on the phase behavior of the system, and (b) which system variables most affect that phase behavior. The presence of hydrophobic solute particles makes micelles form more easily, and that the key variable that determines whether the system encapsulates solute well is the head-solute interaction strength. (ref. Article Encapsulation Efficiency and Micellar Structure of Solute-Ca...
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On the other hand, ionic interaction, and covalent conjugation with the specific polymers can be an efficient strategies for maintaining the encapsulation.
In simple word, the encapsulation efficiency will be based on the type of molecule you want to encapsulate. If we are encapsulating hydrophobic drug in a core, the determination of hydrophobicity of former and vehicle core of micelle your are formulating is essential. Simply encapsulating is not an solution, as your carrier comes in contact with anti-solvent, how long does your system is available to retain the cargo inside itself is equally important. Various polymers are available, encapsulate by systematically increasing the polymers concentration, number or polymers and check the dissolution to access the solubility. Make various groups and compare between solubility and permeability; excessively increasing the polymers may not necessarily increase the permeability of cargo, due to solubility-permeability trade off. Encapsulating is just like playing guitar, if string are too tight it will break, if too loose music will not be produced. At last encapsulation efficiency is the cause; and solubility-permeability are its effects same like gravity is an cause and falling of apple an effect.
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