The current protocol for pulp regeneration shows promising results in terms of healing of periapical lesions and survival rate of treated teeth compared to traditional methods. However, there are several problems with the protocol and the outcomes are unpredictable. Therefore, every step in the treatment protocol should be revised to attain a more biocompatible strategy. More importantly, the effect of adding tissue-engineering triad components (stem cells, bioactive scaffolds and growth factors) to the current protocol needs to be studied in more relevant in situ animal models with immature teeth and concurrent pulp necrosis.