How to remove EDC residual from my reaction? Simple dialysis cant take care of it efficiently.
If your product is not water soluble and acid sensitive, you can try washing with 1M HCl to protonate the EDC which will go into the aqueous layer
Thanks but my polymer is water soluble that's what makes it a bit complicated.
Im working with alginic acid sodium salt so i cant dissolve that in organic media. but thanks for suggestion , appreciate your help
If it's water soluble, then go in reverse, wash the crude with base so the EDC becomes organic soluble and get rid of it.If your compound is acid and base sensitive, then maybe try a non-diimide coupling strategy, like mixed anhydride or acid chloride formation.
thanks a lot for the suggestions, i think i'll go with your first suggestion since mixed anhydrides don't really work with high efficiency in aqueous media
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