Currently, it appears challenging to create mammalian kidney organoids with clear structures known as loop of Henle (LOH). Differences among cultures and difficulties in reproducibility may impede progress, as fully developed kidney organoids only resemble the transcriptional characteristics of the first and second trimesters of human kidney development. However, the implementation of techniques such as microchips with improved vasculogenesis and 3D bioprinting could potentially enhance maturation.
To further advance the development of organoids, are there any potential chemicals or small molecules that could be used to supplement the organoids, apart from prolonging the organoid cultures, in order to facilitate proximal-distal development and the formation of a distinct population of loop of Henle?
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