I am going to give a report about my research plan on the coming PhD program, so I am trying to clarify my research background. I found that there are too many papers relative to my protein or its family members, I don't know where to start.
Try to find two or three reviews and try to get a first impression of your topic. Then you can get into the references and read the original papers. Its sometimes even a good idea to start with an "old" review, when there wasn't as much known about a research field than today. This can make the understanding easier.
As Christian wrote, start with some review, that will give you an overview and probably show some crucial questions in the research. Then continue with original papers and read as many as possible. It's really worth it, because you can discover many forgotten things. Or interpret the results differently than they are usually interpreted.
And there is one thing about reviews I forgot to mention: They usually follow the ideas of the author - which means they can be biased on the papers they review.
@Christian: actually, I'd say that is rather advantage, because usually people review papers of other people (and of course their own as well), so they can show different angle to look at the problem or different interpretation of the data. And of course some sort of meta-analysis is always useful because it combines all the research and serves them on a plate.
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