I usually use ethanol or propanol for dissolution of hydrophobic monomer. and then you nix it with aqueous chitosan solution

Thanks Dmitriy, I’ve tried it with ethanol, DMSO and DMF, but chitosan will precipitate when mixing with these organic solvent

To dissolve chitosan in organic solvents, consider using ionic liquids or modifying chitosan chemically to enhance its solubility. Mixing chitosan with hydrophobic monomers can be achieved by dissolving it in an ionic liquid and then adding the monomer for hydrogel polymerization.

Thanksfor sharing, do you have suggested ionic liquid?

Yes, it is possible to obtain a chitosan-coated compound through actual dissolution A.A.2% with pH 4.5, distillation, and burette processes, taking into consideration placing it in a mixer and continuous stirring at 25 degrees.

We were able to dissolve it in 1-methyl-2-pyrrolidinone (NMP) Article Trimethylated chitosans as non-viral gene delivery vectors: ...