High Protein Bound Drug Produce Inherant Sustained release system?

Drug Protein binding can serve as a reservoir of drug in complex form with protein. Is it work like sustained release?

11 December 2017 7,792 3 View

What are excellent drug candidates for sustained release preparations?

Therapeutic compounds with short half lives are excellent candidates for sustained release preparations. Is it true?

11 December 2017 1,566 1 View

Suggest Best International Conference in Pharmaceutical Field?

I want to present paper in internation conference. Suggest the best international conference outside India?

10 November 2017 6,941 2 View

Is there any influence of pH of body fluid or tissue fluid for disease condition?

From, One newspaper article and also in one magazine (http://sharonglasgow.com/2016/04/no-disease-can-exist-in-an-alkaline-environment/), It is concluded that No disease exist in alkaline state of...

10 November 2017 184 1 View

Is digital tracking pill a future of Pharmaceutical Company?

10 November 2017 4,729 0 View

What is Impact of GST on Pharmaceutical Products in India?

What are impacts in pharmaceutical API manufacturing industry and finished formulation?

10 November 2017 2,956 2 View

In which case, We need to develop Sustained release formulation for drugs having High Half life (24 hr)?

In which case, We need to develop Sustained release formulation for drugs having High Half life (24 hr)?

10 November 2017 2,633 3 View

What is your view regarding Pradhanmantri Jan Aushadhi Store in india? Its successful scheme or not?

Pradhanmanttri Jan Aushadhi Store is an ambitious program conceived and implemented by Govt. of India to provide generic medicines at affordable prices. Pradhanmanttri Jan Aushadhi Store...

10 November 2017 1,642 0 View

Do the dangers of codeine outweight its benefits?

Scientists have raised serious concerns about the widespread use of one of the world's most common painkillers after studies showing that codeine may be unsafe, ineffective and potentially...

10 November 2017 1,786 1 View

Under which circumtances online pharmacy is legal and illegal?

Today, Many company are providing online pharmacy for different category of medicine vice versa many retailers and wholesalers are opposing online pharmacy. I would like to know that under which...

10 November 2017 5,690 5 View

Buffer to disrupt platelet alpha granules for PF4 quantification?

Hello! I want to quantify by ELISA the secreted (from platelets poor plasma) and the non-secreted (from platelet lysate) PF4 before and after TRAP stimulation. I will use the ELISA from R&D...

03 March 2021 1,499 2 View

Buffer Exchange using column packed with sephadex G-25 effect on protein concentration?

Hello, If i am doing a buffer exchange for an antibody of 1mg/mL, does the elution lose protein in the process of buffer exchange? For example, if i flow through 500 uL of 1mg/mL sample, and...

03 March 2021 6,299 3 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

How optimize the Size Exclusion Chromatography?

Hello! I'll do a size exclusion chromatography, but I only have an open column, and I'll perform the peptide extraction from yeast, using buffer lysis (sodium phosphate 50 mM/NaCl 30 mM/DNAse and...

01 March 2021 2,215 2 View

Why are my bands weird in this Agarose gel?

Can someone please give me some possible things that could go wrong? Here is my recipe: 0.5g Agarose 50 mL of TAE 1x 1 uL ethyl bromide. Gel was run at 100V for 1 hour. The buffer used is also TAE.

01 March 2021 9,952 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

What do I do with DLS peaks that are from the buffer?

I'm looking at the aggregation of my protein sample using DLS. Unfortunately, my buffer (20mM HEPES) also results in a set of peaks. These are at approximately 1 and 1000 d.nm. The lowest peak...

01 March 2021 9,015 2 View

What is the most suitable resuspension buffer for TCA/acetone precipitated protein?

I need to extract protein from fermented carbon sources for Bradford assay. Most researchers experiencing insolubility of pellet in resuspension buffer. Please assist me to select most suitable...

26 February 2021 7,129 3 View

What urea buffer can i use for biotagged protein extraction from streptavidin beads?

Hi all, I have been doing research on biotagged LDB1 proteins in Mel cells. I purify the proteins using M280 streptavidin beads. The yield is very low so I've been trying to optimize it by...

24 February 2021 5,749 3 View

Do you kow of any database containing data on retention time, log P and polarizability for a large number of molecules?

Hi, I am a chemistry undergraduate doing my dissertation project on HPLC. In my project, I need to predict the HPLC retention time of 20 aromatic molecules, the calibration set. To do this I will...

24 February 2021 2,602 1 View