Dear Vipul

May be this paper is useful for you

in the link

http://ijdrt.com/public/journals/1/pdfs/sustained-release-matrix-technology-and-recent-advance-in-matrix-drug-delivery-system-a-review.pdf

Hi Vipul, your question is a bit cryptic, but the main parameter of sustained drug levels in the vasculature is mostly dependent on its binding to serum albumin.

If a drug does not bind albumin, its half-life in circulation is measured in min.

http://pubs.acs.org/doi/abs/10.1021/cr940351u

http://ijdrt.com/drug-research-and-technology/article/view/sustained-release-matrix-technology-and-recent-advance-in-matrix-drug-delivery-system-a-review

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