What are excellent drug candidates for sustained release preparations?

Therapeutic compounds with short half lives are excellent candidates for sustained release preparations. Is it true?

11 December 2017 1,566 1 View

Suggest Best International Conference in Pharmaceutical Field?

I want to present paper in internation conference. Suggest the best international conference outside India?

10 November 2017 6,941 2 View

Is there any influence of pH of body fluid or tissue fluid for disease condition?

From, One newspaper article and also in one magazine (http://sharonglasgow.com/2016/04/no-disease-can-exist-in-an-alkaline-environment/), It is concluded that No disease exist in alkaline state of...

10 November 2017 184 1 View

Is digital tracking pill a future of Pharmaceutical Company?

10 November 2017 4,729 0 View

What is Impact of GST on Pharmaceutical Products in India?

What are impacts in pharmaceutical API manufacturing industry and finished formulation?

10 November 2017 2,956 2 View

In which case, We need to develop Sustained release formulation for drugs having High Half life (24 hr)?

In which case, We need to develop Sustained release formulation for drugs having High Half life (24 hr)?

10 November 2017 2,633 3 View

What is your view regarding Pradhanmantri Jan Aushadhi Store in india? Its successful scheme or not?

Pradhanmanttri Jan Aushadhi Store is an ambitious program conceived and implemented by Govt. of India to provide generic medicines at affordable prices. Pradhanmanttri Jan Aushadhi Store...

10 November 2017 1,642 0 View

Do the dangers of codeine outweight its benefits?

Scientists have raised serious concerns about the widespread use of one of the world's most common painkillers after studies showing that codeine may be unsafe, ineffective and potentially...

10 November 2017 1,786 1 View

Under which circumtances online pharmacy is legal and illegal?

Today, Many company are providing online pharmacy for different category of medicine vice versa many retailers and wholesalers are opposing online pharmacy. I would like to know that under which...

10 November 2017 5,690 5 View

How to increase viscosity of solvents like Acetone and IPA?

In one of formulation, I need to improve viscosity of Acetone ans IPA.How to increase viscosity of solvents like Acetone and IPA?

10 November 2017 5,295 2 View

Why might my GFP tag be dissociating from my plasmid after transfection?

I have a set of stably transfected cell lines all transfected with plasmids containing GFP tags on the C terminus. During a western blot using anti-GFP antibody, one of my plasmids has dissociated...

01 March 2021 9,310 4 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Precipitate after adding laemmli buffer to protein solution containing Potassium Acetate?

Hi, I am running a size exclusion chromatography experiment with a buffer containing Potassium Acetate as a salt. I analyse these fractions through SDS-PAGE. After boiling my SEC fractions in...

01 March 2021 2,622 3 View

What is the most suitable server for predicting protein structures in bacteria?

I have used the i-Tasser several times, however it has been unavailable for several days. I tried the swiss-model, but the output was not very pleasant due to the model used. Is there any other...

28 February 2021 4,521 3 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View

Are protein samples in SDS compatible with ELISA?

I have used an AllPrep DNA/RNA/Protein Mini Kit QIAGEN kit to extract RNA and protein from my samples. At the end of the protein purification, I resuspend my protein in 5% SDS. Will these samples...

28 February 2021 7,370 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

RIA. How to measure?

When you use RIA, with a control the unknown sample with antibodies, you bare in mind the binding sites of the antibodies. However you still need to measure labelled antigen (radioactive) and not...

28 February 2021 2,133 3 View

How to replicate the well conditions of a crystal hit with 20%(w/v) isopropanol?

I had a crystal hit in a well with 0.1M HEPEs pH 7.5, 10%(w/v) PEG 4000, and 20%(w/v) isopropanol. Why is isopropanol in w/v here if it's just solvent? How do I recreate this well condition?

25 February 2021 9,761 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View