When designing blocking oligos for NGS hybridization capture assays, would it be sufficient if the sequence of the oligos is complementary to the NGS platform specific adapter sequence? Just wondering because if we are using double stranded library as starting material, then we will technically need blocking oligos that are both complements and reverse complements of the ngs library adapter sequences. Getting confused as in most papers I only see one pair of blocking oligos ( for the 5' and 3' adapter sequences). Any recommendations would be much appreciated. Thanks!