Ayurvedic herbo-mineral formulations are very complex in nature. Even their methodof preparations is also very complex. So in such cases the modern advanced analytical tests are employed to understnad their structure. But is it possible to know the complex structures of the formulations with adopting tests like X ray diffraction, Spectroscopy, FTIR, Scanning electron microscopy etc.
I think, the modern analytical techniques mentioned above, are to be used together in a complementary way to achieve the understanding of the complete picture, each of these instrumental methodologies have several merits and demerits, but when used in conjunction, one can compensate the shortcomings of another.
also, efficient data interpretation and analysis is a big requirement in this regard, Chemo metric tools and machine learning methodologies if made an integral part of the study, can prove to be a valuable asset in this regard.
In my opinion, the first step in analyzing any complex mixture would be HPLC-MS, perhaps measuring high-resolution mass. Then you might decide to isolate at least major components for further structure elucidation - it could be various NMR techniques, X-ray, IR/Raman spectroscopy, or whatever other specific method deemed suitable.
Yes it is possible, Chromatographic techniques follwed by spectroscopic techniques as you mentioned can answer your question.
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