How to deal with high lambda for Multi-trait GWAS analysis?

10 August 2021 0 6K Report

Hello everyone, I have conducted a multi-phenotype GWAS analysis. I have 5 phenotypes in total, the GWAS lambda ranged from 0.8 to 1.12, only two of them are acceptable (0.985, 1.030). Is there any suggestion on how should I deal with this problem?

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