Say finding de novo variation in my white blood cell exome in 2012 vs 2014.
You are right. I refer to the De novo variations between during the timeframe. Any ideas?
Sounds too good to be true, how could the sequencing errors contributed from the sequencing machine be excluded?
Hello,
I think that finding somatic variants in your blood at different timepoints will be virtually impossible unless you're or will be affected by a clonal disorder (which I hope is not the case). The reason is that different somatic variants will accumulate over time on each hematopoietic stem cells (HSC). Given the high number of HSC and the absence of clonality even using an extremely high coverage exome seq, the coverage of real somatic variants will be far below the coverage of artefacts generated by the NGS.
- Badges
- Science topic
- Similar topics
- Computer Science and Engineering
- Bioinformatics
- Bioinformatic Tools