We want to treat hepatocellular cell lines with multiple drugs for approximately 2 weeks. We have the IC curves for each drug for 24 and 48 hours. What concentration, IC value, is considered appropriate for the 2-week treatment?
Agnieszka Bojko
It depends. If your drugs do not cause massive apoptosis, it is a cytostatic agent, then you may choose IC50 or even IC80. You must check how many cells is dying after 48h treatment with given drug in IC50 concentration. If almost all of them, then you must lower the concentration.
0 votes
0 thanks
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Cell Biology
- Culture Cells
- Cell Line
More Danae Zareifi's questions See All
Similar questions and discussions