moxidectin had been used in cattle and sheep, but not in swine. We expect to calculate MRL for Moxidectin in pig in non-radiolabeled residue study. Is there any equation? if concentrations at the time point at which the residues falls below the ADI is MRL? And we found thay the intake consumption at the first sampling time is far below ADI. is it suitable to determine MRL at the first time point? I am so cofused. thank you for your reply.
Dear Xiao,
JECFA, Software-based workbook for statistical evaluation of residue depletion data for veterinary drugs
http://www.fao.org/food/food-safety-quality/scientific-advice/jecfa/guidelines0/residue-depletion/en/
Guideline on determination of withdrawal periods for edible tissues (methodology of calculations)
https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-determination-withdrawal-periods-edible-tissues-revision-1_en.pdf
Comments on JECFA/Codex Alimentarius Statistical methods for the estimation of MRLs
https://www.ema.europa.eu/en/documents/other/comments-jecfa/codex-alimentarius-statistical-methods-estimation-mrls_en.pdf
EMA general MRL guidelines (veterinary drugs)
https://www.ema.europa.eu/en/veterinary-regulatory/research-development/scientific-guidelines/safety-residues/safety-residues-pharmaceuticals#residues-and-withdrawal-periods
OECD, Maximum Residue Limit Calculator (pesticides)
https://www.epa.gov/pesticide-tolerances/oecd-maximum-residue-limit-calculator https://www.epa.gov/pesticide-tolerances/oecd-maximum-residue-limit-calculator
Hope it helps,
Tomasz
there are many measurement to calculate MRI that note in book named ( veterinary MRI).
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