How to accurately test the particle size of carboxymethylcellulose sodium in aqueous solution ? Is there any data for reference ?
Recently, we were conducting experiments related to carboxymethylcellulose sodium. However, when testing the particle size of carboxymethylcellulose sodium, we were confused as the data were quite different.
Kun Li The usual route is dry laser diffraction. It is important to set up a robust, repeatable, and reproducible method with the main parameters to control being the differential pressure and feed rate which govern the dispersion of the powdered material. Main constants are the optical properties. References are ISO 13320 (2020) - Particle size analysis — Laser diffraction methods and ASTM E3340-22 Standard Guide for Development of Laser Diffraction Particle Size Analysis Methods for Powder Materials. You can see a webinar overview (free registration required) here:
PST & BDAS - An acronym approach to laser diffraction method development
https://www.malvernpanalytical.com/en/learn/events-and-training/webinars/W190815PST
https://tinyurl.com/y67v3324
can be employed. Malvern -3000, wet method for correct determination.
If your PSD data is reproducible (in general, minimal sampling No=3), i.e. the same or similar results, with the acceptable RSD, obtained under exactly the same procedure, then it would be fine for your analysis purpose.
Different batches of CMC sodium could possibly have different PSD.
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