I've been preparing the oral dispersible film (ODF) of orlistat. As a solvent system, I'm using ethanol and water in the ratio of 3:1 since orlistat, and the used polymers i.e. PVP-K-90 and HPC dissolve in ethanol. The used one portion water is for dissolving the water soluble ingredients like sucralose (sweetener) and xylitol. Tween 80 was used as a surfactant, and PEG 4000 as a plasticizer. However, the resultant film had oily surface even after drying was carried out for prolonged time. Is it due to tween 80 or PEG 4000? I lowered the concentration of both, but no improvement was observed. The problem has been shown in the picture. What can be tried to get rid of this problem? Thank you.
Add some absorbent material, e.g., silicon dioxide or starch, 2-20% by weightof the matrix
Try with low molecular weight PEG....It will reduce glass transition Tg of your PVP and HPC both..If you use high molecular weight PEG, Tg will increased which should not be happened for ideal film formation
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology