Sandeep Karki

9 Questions 14 Answers 0 Followers

Questions related from Sandeep Karki

How to make Meclizine HCL solubilize in water?

I've been preparing an oral dispersible film of Meclizine HCL (25 mg) that has to be solubilized in water. Unfortunately, it is almost insoluble in water (0.1 mg/ml). I tried using complexation...

09 September 2016 2,311 6 View

How to make the film of hyaluronic acid disintegrates rapidly?

I've been preparing a film of hyaluronic acid intended to administer in the skin. My main objective is to prepare a film that can dissolve really quickly in the skin surface. Despite Hyaluronic...

18 July 2016 9,637 5 View

How the formation of oily like appearance on the film surface can be resolved?

I've been preparing the oral dispersible film (ODF) of orlistat. As a solvent system, I'm using ethanol and water in the ratio of 3:1 since orlistat, and the used polymers i.e. PVP-K-90 and HPC...

15 July 2016 3,668 4 View

What are the strategies for overcoming the crystal formation of drug after complete drying?

I have come up with the problem of crystal formation of Prednisolone sodium phosphate after drying. Prednisolone sodium phosphate is an amorphous solid and freely soluble in water. In my case, I'm...

23 April 2016 1,149 8 View

What are the possible techniques for determining drug release of thin ocular films without using the dissolution apparatus?

For the determination of drug release of ocular films (0.5 cm x 0.5 cm), what are the possible methods that can be used? Using dissolution apparatus would be too big for such a small sized film,...

21 April 2016 7,050 3 View

How to calculate the drug content in the ocular film of Prednisolone Sodium Phosphate?

Can anyone help me to know the standardized method for calculating the drug content in the ocular film of Prednisolone Sodium Phosphate by using UV spectroscopy. Unlike the tablet, how to prepare...

29 March 2016 4,552 1 View

How can I get rid of a virus named ransomware having extension ccc at the end?

Yesterday, my laptop got a deadly trojan virus having extension ccc that affects each of my files. Afterwards, all my files were encrypted to the bizarre format that couldn't be opened by any...

25 November 2015 5,702 5 View

What might be the reasons for a decrease in the viscosity of a composition constituted by synthetic polymers and natural polysaccharides ?

While using the combination of synthetic polymers like Carbopol with naturally derived polysaccharides, I came across to the fact that the viscosity has been going down despite it should have the...

15 September 2015 8,643 6 View

What does one need to keep in mind while picking out the material for 3D bioprinting?

Bio-printing as the latest innovation for fabricating the biological construct on a biocompatible scaffold using state-of-art printing technology for generating tissue of three-dimensional spatial...

28 June 2015 2,311 8 View