How rheumatoid arthritis can be induced in mouse model?

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Jonathan Edwards

Dear Rakesh,

You cannot induce rheumatoid arthritis in mice. It is a human disease whose aetiology relates to complex factors relating to genetic, stochastic and environmental factors operating in the human. You may be able to mimic individual steps in the process in mice but, even there, there is a wide range of uncertainty about relevance. And which step you want to mimic will depend entirely on why you want a model.

Rakesh Kumar Tekade

Dear Dr. Edwards, I agree with you, but I am seeing that some researchers did this by an intradermal injection of 200 μg of bovine type II collagen emulsified in 200 μg of complete Freund's adjuvant given in the base of the tail of male DBA/1J mice to induce rheumatoid arthritis.

I am in need of some references for induction of arthritis. I need to test antiarthritic activity of a herbal formulation..hence i need this model.

Thanks to you and other experts.

Rakesh

Type II collagen arthritis is not rheumatoid arthritis.

If you are testing herbs why not give them to people with rheumatoid arthritis? Why resort to the cruelty of inducing arthritis in animals? If the herbs work in humans you will know straight away.

Joachim, it just says they 'introduced RA into the mice'. I have no idea what they mean by that or how they would have known how to do it. The other articles you quote seem to have nothing to do with human RA. There are 1001 mouse arthritis models, so presumably at least 1000 of them are not RA and as far as I know the other one isn't either!