Human malaria can be caused by any of several species of Plasmodium parasites that occur together in various combinations in regions of endemicity. P. falciparum is responsible for almost all mortality attributed directly to malaria in Tropical India. White blood cell (WBC) counts during malaria are generally characterized as being low to normal, a phenomenon that is widely thought to reflect localization of leukocytes away from the peripheral circulation and to the spleen and other marginal pools, rather than actual depletion or stasis. Leukocytosis is typically reported in a fraction of cases and may be associated with concurrent infections and/or poor prognosis. Remarkably few published studies have compared WBC counts in malarial parasite–infected and –uninfected residents of regions in which malaria is endemic, however. no one report from the science that, How the platelets count decrease rapidly during the malaria? and how they increase very rapidly after the treatment? Is it possible? We know very well that low platelet counts are often seen in malaria patients in the early stages of infection. In my view, there is only the aggregation of platelets and some times they compromise with the host by mediating adhesion of infected erythrocytes to the vascular wall. Thus, platelets bind to infected red blood cells and are taken out of circulation so called inactive at that time.