Human malaria can be caused by any of several species of Plasmodium parasites that occur together in various combinations in regions of endemicity. P. falciparum is responsible for almost all mortality attributed directly to malaria in Tropical India. White blood cell (WBC) counts during malaria are generally characterized as being low to normal, a phenomenon that is widely thought to reflect localization of leukocytes away from the peripheral circulation and to the spleen and other marginal pools, rather than actual depletion or stasis. Leukocytosis is typically reported in a fraction of cases and may be associated with concurrent infections and/or poor prognosis. Remarkably few published studies have compared WBC counts in malarial parasite–infected and –uninfected residents of regions in which malaria is endemic, however. no one report from the science that, How the platelets count decrease rapidly during the malaria? and how they increase very rapidly after the treatment? Is it possible? We know very well that low platelet counts are often seen in malaria patients in the early stages of infection. In my view, there is only the aggregation of platelets and some times they compromise with the host by mediating adhesion of infected erythrocytes to the vascular wall. Thus, platelets bind to infected red blood cells and are taken out of circulation so called inactive at that time.
Dear Mohammad Jalaluddin Abbas, very interesting question. Wish all success in your study.. please follow the links below
Platelet activation determines the severity of thrombocytopenia in dengue infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282509/
Thrombocytopenia in malaria and its correlation with different types of malaria Gill MK, Makkar M, Bhat S, Kaur T, Jain K, Dhir G - Ann Trop Med Public Health
http://www.atmph.org/article.asp?issn=1755-6783;year=2013;volume=6;issue=2;spage=197;epage=200;aulast=Gill
Degue - A mosquito based viral fever .
For Details :
https://www.researchgate.net/post/Degue_Fever-A_Mosquito_based_Viral_Fever
A very Good natural remedies of platlet enhancer is Carica Papaya - An extract of
an important enzyme Papain.
Hypothesis that malaria parasite produces factors that reduce the platelet production from the megakaryocytes. This saves the parasite from the platelet
mediated clearance as a survival mechanism.
Platelet indices suggest that both peripheral destruction of
platelets and possible bone marrow suppression play role
in causing thrombocytopenia in Dengue patients
Thrombocytopenia was noted in 63.33% cases. The mean platelet count in Plasmodium vivax (Pv) malaria was 1,27,652/μl (SD 78,269) with a range of 8000-3,50,000/μl, as against Plasmodium falciparum (Pf) malaria where the mean platelet count was 78,500/μl (SD 51,485) with a range of 9000-1,90,000/μl. Platelet count < 50,000/μl was noted in only 17.4% cases of Pv malaria as against 33.3% cases of Pf malaria
Thrombocytopenia is another clinical manifestation and is common in patients with either mild or severe cases of DENV infections. Studies suggest that the low platelet count is one of the major causes of bleeding in these patients. The platelet counts drop below normal level (150,000–450,000 platelets/μL) and may reach as low as
Hello Mohammad Jalaluddin Abbas,
Thrombocytopenia (low platelet count) is often associated with human malarial infection.
For details as to why this occurs and why platelet increases during treatment, please read this article publish by Simon Foote of Menzies Research Institute :
https://www.hhmi.org/news/blood-platelets-can-kill-malaria-parasites
Dear @ Mohammad,
#Decreasing the platelet count - It is because of the reaction to the virus that platelets might fall in dengue. As you know, The normal platelet count is 1.5 lakhs to 4 lakhs. During the dengue fever, the platelet counts may fall. If the platelets were dropping them it would give an outward reaction in the form of "Dengue Hemorrhagic fever". When the platelets are dropping, red color rashes are developing on the body. These rashers can come everywhere on your body like on the face, abdomen, neck, and arms, etc. If the number of platelets was observed less than 10,000 or 20,000 then there are the chances of bleeding like bleeding gums or bleeding nose. So, these are the easy symptoms for example- when you hit something, then there is a small red color patch on your hand. Hence, monitoring the platelet count is a very crucial step in this outbreak.
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