Have a look on this interesting file:

http://www.masteringdiabetes.org/insulin-sensitivity-101-retreat-results/

Thanks for your responses.

Does anyone have any links to papers or academic sources?

Most people think that 4 days is not enough to see dramatic improvements in blood glucose, energy levels or weight loss. I’ll be the first to admit that when we started our diabetes retreats, we thought the same thing.

However, after reflecting on the rapid improvements in blood glucose and speedy decreases in insulin need that many of our clients experience, it became obvious that rapid increases in insulin sensitivity are possible in as little as 24-48 hours.

Insulin sensitivity is calculated as the ratio of your total carbohydrate intake to your total insulin use (basal and bolus) in a 24-hour period. This number is calculated only when you maintain your blood glucose in the normal range (70-130 mg/dL) for more than 80% of the day. The calculation is shown here:

Most people think that 4 days is not enough to see dramatic improvements in blood glucose, energy levels or weight loss. I’ll be the first to admit that when we started our diabetes retreats, we thought the same thing.

However, after reflecting on the rapid improvements in blood glucose and speedy decreases in insulin need that many of our clients experience, it became obvious that rapid increases in insulin sensitivity are possible in as little as 24-48 hours.

Insulin sensitivity is calculated as the ratio of your total carbohydrate intake to your total insulin use (basal and bolus) in a 24-hour period. This number is calculated only when you maintain your blood glucose in the normal range (70-130 mg/dL) for more than 80% of the day. The calculation is shown here:

📷

Our attendees results speak for themselves. In this article, we’ll share the change in insulin sensitivity that occurred at our last diabetes retreat in 7 insulin-dependent attendees living with either type 1 or type 2 diabetes.

We teach all of our attendees to fill out a daily Decision Tree, a food, exercise and medication dosing log that provides us with detailed information about their blood glucose patterns over the course of a 24-hour period. The process is designed to provide both the attendee and us detailed information about how their insulin sensitivity changes over time as they improve their eating and movement habits.

By analyzing this data on a daily basis, we are able to visualize how a low-fat, plant-based, whole-food diet can promote significant improvements in insulin sensitivity in a short period of time. This provides everyone with insight about how to reduce oral medication and insulin use while maximizing whole carbohydrate intake from unprocessed fruits and vegetables.

Please note that the names of each attendee below has been removed to protect their identity and personal health information. The data was recorded in detail over the course of the 4-day diabetes retreat, and all data are averages of the 4-day period. All personal information has been .

Insulin sensitivity = 24-hour carbohydrate intake /24-hour insulin usage

📷

Our attendees results speak for themselves. In this article, we’ll share the change in insulin sensitivity that occurred at our last diabetes retreat in 7 insulin-dependent attendees living with either type 1 or type 2 diabetes.

We teach all of our attendees to fill out a daily Decision Tree, a food, exercise and medication dosing log that provides us with detailed information about their blood glucose patterns over the course of a 24-hour period. The process is designed to provide both the attendee and us detailed information about how their insulin sensitivity changes over time as they improve their eating and movement habits.

By analyzing this data on a daily basis, we are able to visualize how a low-fat, plant-based, whole-food diet can promote significant improvements in insulin sensitivity in a short period of time. This provides everyone with insight about how to reduce oral medication and insulin use while maximizing whole carbohydrate intake from unprocessed fruits and vegetables.

Please note that the names of each attendee below has been removed to protect their identity and personal health information. The data was recorded in detail over the course of the 4-day diabetes retreat, and all data are averages of the 4-day period. All personal information has been removed.

Hi Terun,

Insulin sensitivity is a dynamic parameter, which means that it varies in correlation to physiological stimulus. In one study, insulin sensitivity as estimated by the euglycemic hyperinsulinemic clamp study changed within a short time (Approximately 2 hours) after the administration of norpinephrine. In some evaluations that our group has conducted, we have observed changes in insulin sensitivity within a week of exposure to medication that improves sensitivity. Now if you consider the reversibility of insulin resistance instead the question changes, as data has shown that the changes are more gradual and can take months to ensue. These following publications might be useful for your inquiries:

Article Quantification of Insulin Secretion in Relation to Insulin S...

Article Restoration of Euglycemia and Normal Acute Insulin Response ...

Article Induction and Reversibility of Insulin Resistance in Rats Ex...

Article Reduction in insulin sensitivity following administration of...

I hope you find these useful.

Insulin sensitivity (measured using gold-standard hyperinsulinemic-euglycemic clamp) changes dynamically to various conditions- fasting Vs fed Vs exercise Vs sleep. For the anti-oxidant supplementation taken orally to reach a meaningful level in plasma (gastric emptying time, intestinal absorption rate and its half-life), it would have be multiple doses like the investigators used here: Article Effect of antioxidant supplementation on insulin sensitivity...

So I am guessing there would be very modest, if not no, effect on insulin sensitivity per se.

I completly agree that insulin sensitivity is very dinamically altered by many physiologically or pathologic conditions. In dogs, secondary diabetes as result of higuer progesterone and GH levels is very commom during diestrus in intact females. When we remove the source of those antagonic hormonal stimuli, many bitches achiev diabetes remission, sometimes few days after surgery. This paper may help...