How much normality of HCl can peptides tolerate upon heating before they hydrolyse?

09 September 2013 1 5K Report

Is it possible to heat proteins in 100 mM HCl without hydrolysing them? Usually the reaction is done at 110 C at 6M HCl.

Sharad Purohit

Some degradation may occur especially if the peptides have basic aa in their structure.

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