As cerium oxide nanoparticles insoluble in water but soluble in conc.acids. Though it soluble in acids but not feasible to treat for invitro cells.
What other possibilities to dissolve metal oxide NPs for invitro studies?
You can use a complex compound of cerium citrate. If the ratio Ce: Cit = 1: 2, the reaction proceeds to form a soluble complex compound according to the equation:
Ce3++ 2C6H5O73- = [Ce(C6H5O7)2]3-
The precipitate of cerium citrate released during the first stage gradually dissolves upon addition of the second half of the sodium citrate solution.
Did you buy those NPs or are they from synthesis?
In the first case, buy some CeO2 NPs dispersions in water (there are many supplier). In the second case, use a capping agent that makes the NPs dispersible in water.
Some references are enclosed
Article Dissociative Binding of Carboxylic Acid Ligand on Nanoceria ...
Article Precipitation-Redispersion of Cerium Oxide Nanoparticles wit...
You can use a complex compound of cerium citrate. If the ratio Ce: Cit = 1: 2, the reaction proceeds to form a soluble complex compound according to the equation:
Ce3++ 2C6H5O73- = [Ce(C6H5O7)2]3-
The precipitate of cerium citrate released during the first stage gradually dissolves upon addition of the second half of the sodium citrate solution.
Mostly the metal oxide of nanoparticles can not dissolve in conc. acid ... some time it is dissolved in HF ...........
HCl, HNO3, H2SO4, HF may partially dissolve CeO2 at ambient conditions. I would recommend aqua fortis (H2O2+HNO3, 1:1ratio by volume) for complete dissolution. Please take time to know the handling techniques and be aware first to handle such explosive chemicals.
Its not clear that you need a solution of nanoparticles or stable dispersion of nanoparticles in water. You can prepare a stable dispersion of nanoparticles by capping the surface of those with water soluble capping ligands like mercapto acetic acid.
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