How long does it take to induce Diabetic Cardiomyopathy using STZ in rats?

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Wei Wen Lim

Should be around 12 weeks after STZ but may depend on the dose, rat strain, age and gender..

Ref:

1) Dong, Bo, et al. "Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy." Journal of the American College of Cardiology 59.8 (2012): 739-747.

2) Lin, Guorong, et al. "Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats." Cardiovascular research 75.1 (2007): 51-58.

Isehaq Al-Huseini

I agree with Dr. Wei Wen

You might be able to see significant difference in LV internal dimension after 12 weeks

hope these references would help

1. Akula A, Kota MK, Gopisetty SG, Chitrapu RV, Kalagara M, Kalagara S, Veeravalli KK, Gomedhikam JP. Biochemical, histological and echocardiographic changes during experimental cardiomyopathy in STZ-induced diabetic rats. Pharmacol Res. 2003 Nov;48(5):429-35. doi: 10.1016/s1043-6618(03)00191-9. PMID: 12967586.

2. Rodrigues B, Cam MC, Kong J, Goyal RK, McNeill JH. Strain differences in susceptibility to streptozotocin-induced diabetes: effects on hypertriglyceridemia and cardiomyopathy. Cardiovasc Res. 1997 Apr;34(1):199-205. doi: 10.1016/s0008-6363(97)00045-x. PMID: 9217891.