I want to know how Max may be regulated at the transcriptional level (by transcription factors). What are factors that inhibit or promote Max expression on the trascriptional level?
Miao et al. found that Max expression is epigenetically regulated. Hypermethylation of cis-regulatory sites in the MAX promoter region result in the down-regulation of MAX mRNA ("Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic")
However, Bernhard Lüscher and Jörg Vervoorts mention in their review "Regulation of gene transcription by the oncoprotein MYC" that "The expression of MAX is somewhat uninspiring in the sense that this protein is ubiquitously expressed at rather high levels (. Nevertheless there have been a few reports that suggest regulation of MAX at the posttranslational level."
Are there known transcription factors regulating the expression of MAX at the transcriptional level?
I don't know the MAX field well, but the two papers you mentioned are not contradictory. A gene (e.g. MAX) may show ubiquitious expression in normal tissues (2nd paper), but still could become silenced by DNA hypermethylation in cancer (1st paper).
The transcription factors regulating the expression of MAX will depend on the cell type you are interested in. The ENCODE database provides with a huge set of ChIP-Seq data in different cell types for many TFs. You can maybe have a look there. To reach it, you need to go the ucsc genome browser.
Apart from the ENCODE data, we also published some more ChIP-Seq for neural stem cells: http://genome.cshlp.org/content/25/1/41.full
These data are accessible also via the UCSC genome browser using our Track Hub: http://genome-euro.ucsc.edu/cgi-bin/hgTracks?db=mm9&hubUrl=http://www.nimr.mrc.ac.uk/trackhub/cisstemhub/hub.txt
You can see that several of the factors we study are detected close to the transcription start site of the MAX locus.
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