According to WHO research, 20 million people in Bangladesh use tobacco in some capacity, and 57,000 people pass away each year from diseases linked to tobacco use, with oral cancer ranking second among men and third among women in terms of cancer incidence.
Uric acid is the end product of purine metabolism in humans. The normal concentration of uric acid in the serum adults is in the range of 3-7 mg/dl. In women, it is slightly lower (by about 1 mg) than in men.The possible protective action of many of the natural antioxidants that are found in biological fluids and tissues has been the subject of intense investigation. The effect of serum uric acid on aetiology of cancer may vary from one type of cancer to another; low serum uric acid may be associated with increased risk of lung and oral cancer for instance while high serum uric acid may be associated with increased risk of other types of cancer.
In recent years, attention has been concentrated on finding molecular markers in blood, saliva, urine, and others that can be used to diagnose diseases. Many researchers have noted a connection between serum uric acid and various malignancies.
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But Generally speaking, serum uric acid (SUA) is a metabolic byproduct of purine metabolism and is typically associated with conditions like gout and kidney stones. The relationship between serum uric acid levels and oral squamous cell carcinoma (OSCC) is complex and can be influenced by various factors. However, research suggests that there might be a connection between elevated SUA levels and OSCC. Here's a general overview:
1. Inflammation and Oxidative Stress:OSCC is a type of cancer that originates in the cells lining the oral cavity. Chronic inflammation and oxidative stress are factors that contribute to the development and progression of cancer. Elevated serum uric acid levels have been associated with increased inflammation and oxidative stress in the body. Inflammation and oxidative stress can promote cancer development by damaging DNA and creating an environment that supports tumor growth.
2. Potential Biomarker:Some studies have explored the use of serum uric acid as a potential biomarker for cancer, including OSCC. Elevated SUA levels have been observed in cancer patients, and there is ongoing research to investigate whether SUA levels can be used as a diagnostic or prognostic marker for various cancers, including OSCC.
3. Tumor Growth and Metastasis:There is evidence suggesting that uric acid may play a role in tumor growth and metastasis. Uric acid can act as a pro-inflammatory molecule and may promote angiogenesis (the formation of new blood vessels to supply tumors) and tumor cell invasion. These factors contribute to cancer progression and metastasis.
4. Treatment Response:Some research suggests that elevated serum uric acid levels could impact the response to cancer treatments. High uric acid levels might affect the efficacy of certain chemotherapy agents, potentially influencing treatment outcomes.
It's important to note that while there is some evidence suggesting a link between serum uric acid levels and OSCC, research in this area is still ongoing, and the exact mechanisms and implications are not fully understood. Additionally, other factors such as lifestyle, genetics, and comorbidities can influence SUA levels and cancer development.
If you're interested in this topic, it's recommended to consult recent scientific literature or medical professionals who specialize in oncology to get the most up-to-date and accurate information regarding the relationship between serum uric acid levels and oral squamous cell carcinoma. Fazlay Rabbani
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