How does HLA influence the response to hepatitis B vaccine among the different ethnic groups throughout the world?

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Gautam Ray

HLA 1 and 2 are present on immune cells and these are needed to mount both active and passive immunity on exposure to any infectious agent [antigenic part of the agent is presented to the T and B cells by APCs in conjuction with HLA for this]. As there may be different alleles of HLA in different ethnic groups [different immunotype in different individuals], so the immune response also varies. Same is the case with vaccines.

Gasim Ibrahim Gasim

Dear Gautam Ray , thank you for reply. However this raises another question about mapping this effect worldwide or in other words has this relation ever given any concern by reaserchers?