As we know that Actinomycetes produce most of the clinical used antibiotics, therefore, what mechanisms do they use to protect themselves from the antibiotics they made?
Anita Ma It is long-known fact that antibiotic-producing bacteria have powerful system of multiply resistance to toxic compounds. See some references:
Benveniste, Raoul, and Julian Davies. "Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria." Proceedings of the National Academy of Sciences 70.8 (1973): 2276-2280.
HOTTA, KUNIMOTO, et al. "Multiple resistance to aminoglycoside antibiotics in actinomycetes." The Journal of Antibiotics 36.12 (1983): 1748-1754.
Antibiotic-producing Actinomycetes protect themselves from their own antibiotics through mechanisms such as efflux pumps that expel the drugs, chemical modifications that render them inactive, and target site alterations to prevent binding. Additionally, they may utilize prodrug strategies and temporal-spatial shielding to minimize self-exposure to the toxic effects of the antibiotics they produce.
Actinomycetes as antibiotic producers have self-resistance mechanisms against their own antibiotics (examples of references: [1] Stegmann E, Frasch H-J, Kilion R, Pozzi R. Self-resistance mechanisms of actinomycetes producing lipid II-targeting antibiotics. Int J Med Microbiol 2015;305:190-5. [2] Cundliffe E. Self-protection mechanisms in antibiotic producers. Ciba Found Symp 1992;171:199-208.) or have cascade and networks of regulatoey genes that control antibiotic biosynthesis (Ref. Martin JF, LirasP. Subcell Biochem 2012;64:115-34).
- Badges
- Science topic
- Similar topics
- Biological Science
- Biota
- Eukaryota
- Fungi