Several times
I lost my sample during freeze drying. There was no solid or powder in the vial after freeze drying. I'm sure sample contained solute because i took its NMR spectrum. I covered the vial with a perforated parafilm. Top of the vial is clean and there is no evidence of solid getting out. does anybody has an idea?
Rob Darrington
Generally there are 2 answers to this -
1. "blow out" due either rapid vacuum release or increasing cake resistance creating a "wind" to push the powder out .... unlikely in the case where you use perforated film over the vial
2. subllimation of your product, depending on whtat it is. MW
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Duried Alwazeer
Try to keep your extract at -80°C freezer for a couple of hours before putting it in the lyophilizator.
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