Dear All,
I'm using DMBA/TPA to induce the skin cancer in Balb/C mice, I would like to know how does my compound of interest in inhibiting the growth of tumors. What are the mechanisms that are involved in the inhibition of the cancer in the skin of Mice.
Please help me to get a clear concept of this phenomenon.
Thank You
It depends on the chenopreventive agent: some of them have antioxidant potential, another- influence DNA repair or proliferation rate or immunity. What kind of agent you use for skin tumor prevention?
It is really difficult to know the exact mechanism/s involved in the antitumor effects of one compound. You probably will only relate the compond effects with any route you are able to analyze. For example, if you are able to detect effects on oxidative stress, you get a relationship, but most probably it is not the only one.
Dear Dr. Anisimov,
Thanks for your reply.
Im using a synthetic dye as an anti-cancerous agent, with DMBA/TPA model.
I do not understand well the question and the responses.
A "chemopreventive" agent is an agent that avoid growth development. Experimentally, a chemopreventive agent is given BEFORE grafting or inducing the tumor model in vivo.
A chemopreventive agent's purpose is therefore not to inhibit tumor growth but to limit / prevent tumor apparition.
A chemotherapeutic agent's purpose is to inhibit tumor growth. It is experimentally given AFTER tumor occurence.
Are we thus actually speaking about "chemopreventive agents" in the cancer field?
Best regards
Robert
Dear Vladimir,
In an ideal World, what would be your choice of language for the world scientific community ... ? ...
Robert
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