This issue is important because this benign tumor-like nosology has a good prognosis and tendency to spontaneous regression without any treatment. However, differential diagnosis with chondromyxoid fibroma, chronic osteomyelitis or even osteoclastoma may come in consideration. How can you be sure that a given patient has a non-ossifying fibroma and needs no treatment ?
I think that WHO 2013 classification of Soft tissue and bone tumors can answer this quistion better than all.
I also recommend this article - full text is available. Good luck!
Bowers LM, Cohen DM, Bhattacharyya I, Pettigrew JC Jr, Stavropoulos MF. The
non-ossifying fibroma: a case report and review of the literature. Head Neck
Pathol. 2013 Jun;7(2):203-10. doi: 10.1007/s12105-012-0399-7. Epub 2012 Sep 25.
Dr. Rotin, my question tackles the precise diagnosis of a non-ossifying fibroma in the practice and not classifications, clinical picture, etc. In my opinion a well experienced orthopaedic surgeon who is familiar with bone tumors and tumor-like lesions would orient himself/herself according to clinical signs and x-ray characteristics of a suspective non-ossifying fibroma. The patient should be followed-up. Unfortunately, in some cases biopsy is needed to exclude other bone tumours and confirm the histological diagnosis of a non-ossifying fibroma which in the majority of cases heals spontaneously.
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