Dear colleagues, I've browsed a lot of papers and encountered the fact that when the both primary and metastatic tumors are of interest for researchers and when the xenograft model is involved, metastasis in achieved by the direct tail vein injection of the cell suspension. Yet, xenograft tumor itself seems to be fully capable of forming metastases. So the question is - do xenograft tumors spread metastases? Or does it take too long for them to do it, so it is impossible in most investigations to detect them, as establishing metastatic tumors is surely challenging.

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