Our earlier X-ray crystallographic studies of drug-DNA complexes at the University of Rochester have led to an understanding of the dynamic structural mechanism that allows planar drugs and dyes to intercalate into DNA. This same mechanism explains the physical basis of DNA "breathing" and "melting" -- deepening our understanding of the initiation, elongation and termination of RNA synthesis by the RNA polymerase accompanying transcription. Finally, it explains how actinomycin interferes with DNA transcription -- and in so doing -- suggest that trace amounts of actinomycin given over an extended period of time be a powerful anticancer regimen in the treatment of many different kinds of cancer.
WE HAVE ANSWERED THE QUESTIONS RAISED ABOVE , AND IN SO DOING HAVE PROPOSED A LARGER CONCEPTUAL THEORY TO UNDERSTAND KEY QUESTIONS IN MOLECULAR BIOLOGY.
Could you please provide some references for the larger conceptual theory;
Best regards
Dikeos Mario
Version:1.0 StartHTML:0000000158 EndHTML:0000040708 {page:WordSection1;} -->
Begin by clicking on to my video presentation:
https://youtu.be/-MEMM_-kUWg
After this go to my website: http://henrymsobell.com/
clicking on to Book 1, Book 2, along with my JSFB (2016) paper.
Many thanks for your questions.
Henry M. Sobell
Begin by clicking on to my video presentation:
https://youtu.be/-MEMM_-kUWg
After this go to my website: http://henrymsobell.com/
clicking on to Book 1, Book 2, along with my JSFB (2016) paper.
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Biology
- Biomolecules
- Nucleic Acids
- DNA