The increase of the ligand increases the receptor and the enzyme or only one or the other.
Hi Enrico! I believe it depends very much on your experimental conditions! Are you working with cells or animals? Which type of cells/tissue? Which ligand are you using, is it an endocannabinoid (i.e. anandamide), a sinthetic agonist or an antagonist?? How long is your treatment, acute or chronic?
I do really believe the results may be very variable depending on all these factors!! For example a chronic treatment with THC is known to downregulate CB1 receptor expression and functionality!
Hope this was helpful!
Best,
Natalia
Our studies in rodent models suggest that chronic treatment with direct (THC) and indirect agonists (e.g. FAAH inhibitor) decrease the density of CB1 receptors.
Do you think your observation in vitro may indicate the same behavior in vivo?
From the study of the literature it seems that this statement is not correct. The concentration of endocannabinoids would affect the receptor level but the effect of the variation of endocannabinoids would be different depending on the local microenvironment.
In vivo do CB1 and FAAH vary in parallel or in revers ?
Please read our work on AJOG and send me a comment. Many thanks in advance
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