How did the AAV therapy last a long time on patient with once injection?

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Audrey Quashie

This is because tge transgene expressionwas maintained for a long period in the injected patient.

Fei Li

@ Audrey Quashie

How？

It is due to hypomethylation which is the loss of the methyl group in 5-methylcytosine by DNA methyltransferase 1 resulting in an increase in the rate of mitotic chromosomal recombination.