I am working on cerebral malaria in mice,i need to know if there is any other method of recording chills and rigors in parasitized mouse other than visual subjective observation with respect to control
In addition place a light object on the mice and observe for vibrations that go with rigors. You can also check on their body temperatures.
Dear Mansi,
My feeling is that human malaria and mice malaria show both a high diversity of clinical manifestations, and that symptoms are evolving in hours or minutes, leading to high variability. Thus I don't think that it could be relevant to record chills and rigor with a non-subjective method. There are different clinical scales that have been published (one is from AL BIENVENU, from my team), that provide stages relevant to most of the experimental goals.
- hello sir..i usually record the chills in mice malaria qualitatively i.e subjective to the control.however, i am really interested to know about the different clinical scales published in relevance to non subjective recording of the observed general morbidity.can you please help me with the respective person's email id or their publication link.....
Dear Mansi, you can download:
Bienvenu AL, Picot S.Methods Mol Biol. 2013;982:315-24. doi: 10.1007/978-1-62703-308-4_19.
Bienvenu AL, Ferrandiz J, Kaiser K, Latour C, Picot S. Acta Trop. 2008 May;106(2):104-8. doi: 10.1016/j.actatropica.2008.02.001.
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