We can estimate LC50 (which is in concentration) of a drug from Zebrafish acute toxicity. Can any researcher suggest how to determine the therapeutic dose (mg or g/kg) of rodent or human from the LC50 values.
Firstly, correcting your question..the therapeutic dose would be applicable for humans only. Now, moving on to the answer part..research in the field of using zebrafish as a model for toxicity testing has not moved at such a stage where it could be used to extrapolate therapeutic dose for humans or for deciding toxicity dose-range for rodent assays.