How can we arrange the pH of chitosan solution to use it in human body?????(because chitosan solution is acidic and toxic for our body)?
Dear Nisa,
As you comment chitosan is soluble only at acidic pHs. I do not know if it is an option for you... but maybe you can try to chemically modify chitosan to obtain carboxymethyl chitosan or lactate chitosan (https://doi.org/10.1016/j.msec.2020.111716). These two polymers are soluble at neutral pHs and are biocompatible. We use them in our biomaterials group because of their excellent properties.
Hope I have been helpful.
Yours sincerelly,
Daniel
Dear Nisa,
I think that the answer provided by Daniel can help you to obtain a chitosan-derivatives soluble under physiological conditions with pH higher than 6. However, you need to control the substitution degree to not impairs the biological properties found in raw chitosan. In addition, changing the degree of deacetylation and/or the molecular weight of chitosan can be an alternative. See this paperArticle Effect of degree of deacetylation on solubility of low molec...
).Good work,
Regards, André
We use 0.1 N NaOH to arrange the pH when making edible film from chitosan. You can try it.
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