I am doing a acid and a chiral amino alcohol reaction using DCC and HOBT in DCM or THF? Can anyone suggest me how to remove DCU and HOBT from a reaction mixture??
Dear Sanjay Adhikari many thanks indeed for your interesting technical question. The by-product dicyclohexyl urea often crystallizes out upon cooling of the reaction mixture in the refrigeratot when the reaction was carried out in dichloromethane. In that case it can be easily removed by filtration. If this doesn't happen in your case, it might be a good idea to use EDC (1-ethyl-3-(3' dimethylaminopropylcarbodiimide hydrochloride) instead of DCC as suggested by Carlos F. Marcos
. N,N'-diisopropylcarbodiimide (DIC) is another suitable alternative.The following review article provides a comprehensive overview about the different couling reagents.
Article Large-Scale Applications of Amide Coupling Reagents for the ...
Unfortunately I don't have access to the full text of this paper.
However, I found an alternative references entitled:
Coupling Reagents
This paper also provides useful hints. For your information please find attached a pdf file of this paper.
Please also note that there are several closely related question on RG which you could check out for additional answers, e.g.
How do I completely remove DCU from the reaction mixture without coloumn chromatography?
https://www.researchgate.net/post/How-do-I-completely-remove-DCU-from-the-reaction-mixture-without-coloumn-chromatography
How can I remove the DCU after an esterification catalyzed by DCC ?
https://www.researchgate.net/post/How_can_I_remove_the_DCU_after_an_esterification_catalyzed_by_DCC
and
How can I remove DCU (dicyclohexyl urea) by product formed during estrification reaction via (DCC/DMAP) with carboxylic acids?
https://www.researchgate.net/post/How_can_I_remove_DCU_dicyclohexyl_urea_by_product_formed_during_estrification_reaction_via_DCC_DMAP_with_carboxylic_acids
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