Hello I want to ask about particle size reducing,
İ am working on SLN , while i prepare SLN uses "hot homogenization and hot prob sonication technique" but my particle size does not go below 200 nm. My expectation is to go below 100 nm. My surfactant is PLX188 (İ tried tw80 sp 80 plrunic F127, tw20, Cremphor EL Cremephor RH40)
İ am waiting for your answer ASAP
Thank you