I am studying efficacy of TB drugs to disseminate in various organs after drug administration either orally or via IV route. Main aim is to study how much concentration actually reaches the organs after administration for prevention of pulmonary and extra pulmonary TB. Can anyone suggest some good protocols??
Measurement of serum level concentration would most suitable. As Cmax is described by maximum achievable concentration. It is part of Pharmacokinetics routine studies and could well be achieved by MS or HPLC in my opinion.
Difficult but important question. What seems to matter are not only organ concentrations but concentrations in the actual lesions. Veronique Dartois' papers provide interesting reading, e.g. http://www.ncbi.nlm.nih.gov/pubmed/24487820http://www.ncbi.nlm.nih.gov/pubmed/24487820 and http://www.ncbi.nlm.nih.gov/pubmed/21986820
Not sure in which species you are working. Mice usually don' t produce human-like lesions (except for Kramnik mice) and also the lesions are too small
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