I have prepared cationic niosomes composed of surfactants and DC-Cholesterol but i found these niosomes were not stable and tend to agregates in a couple of days although the ZP was around 75mV, so does any one has an explaination of that and how can i increase their stability?
thanks
I have to use a buffer ir water because this is intended for IV application.
first check the viscosity of niosomes fluid, viscosity of commonly used intravenous solutions range from 1.0 centiPoise to 40.0 cP. and check by changing the storage conditions (temp) and pH for stability. Any how, water is not a good continuous phase, and try the isotonicity contribution to niosomes, it may helpsby tangeling the surfaces of niosomes to avoid aggregation
The stability of niosomes could be altered by surfactant to cholesterol ratio. selection of surfactant type, span 60 has been to be the best of its congers.
- prepare them in a freeze dryed formf or longer term stability.
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